Advantix comes in packs of four or six. [3] X Research source Small dogs (4 to 10 pounds) – 0. 4 milliliters (mL) [4] X Research source Medium dogs (11 to 20 pounds) – 1. 0 mL[5] X Research source Large dogs (21 to 55 pounds) – 2. 5 mL[6] X Research source Extra-large dogs (over 55 pounds) – 5. 0 mL[7] X Research source

Placing the upside-down cap back on the tube will break the seal on the top of the tube, allowing you to squeeze out the Advantix. [10] X Research source When you see that the seal has broken, remove the cap from the tube and lace it to the side. [11] X Research source

Small and medium dogs will need three Advantix applications along their backs. [14] X Research source Large and extra-large dogs will need four Advantix applications along their backs. [15] X Research source If your dog is extremely furry, it may be helpful to clip away a little bit of hair to make it easier to apply the Advantix.

Advantix should not be applied if the skin is wet or broken. [17] X Research source Dry your dog’s skin if it is wet. If the skin is broken, do not apply the Advantix and contact your veterinarian. It is not necessary to massage the product into the skin after applying it. [18] X Research source Another reason not to massage the product into your dog’s skin is that Advantix can be harmful to human skin. [19] X Research source The remaining applications should be spaced at least a few inches apart down your dog’s back. For large and extra-large dogs, the last dose should be near the top of the tail. For small and medium dogs, the last dose should be near the middle of the back. [20] X Research source Avoid petting the dog for several hours after application, as you may wipe the product off the skin. It might be best to apply Advantix shortly before the dog goes to bed to minimize the chances of accidentally wiping it off.

The remaining tubes that were not used should be stored at room temperature in a cool, dry place. [22] X Research source

Even though Advantix is waterproof, it will take at least two days before it has absorbed enough in the skin so that it will not come off with bathing or swimming.

If you have other pets, keep your dog separated them so that they do not have a chance to ingest the Advantix or get it on their skin.

If your dog has any of these side effects, take your dog to your veterinarian. [28] X Research source