Intranasal steroids (INS) like Flonase act on many inflammatory substances and help block the body from producing them while antihistamines block only the histamine release.

Nosebleeds are the most common side effect from using Flonase. [3] X Trustworthy Source Mayo Clinic Educational website from one of the world’s leading hospitals Go to source If you experience other side effects from the medication, such as cough, fever, headache or muscle aches, sore throat, or fatigue, see your doctor. [4] X Trustworthy Source Mayo Clinic Educational website from one of the world’s leading hospitals Go to source

Cataracts (clouding in the lens of your eye) Glaucoma (an eye fluid-pressure disease) Current nose sores Any type of untreated infection Herpes infection in the eye Recent nose surgery or injury Previous diagnosis of tuberculosis (a type of infection) in your lungs Pregnancy, breastfeeding, or plan to become pregnant. If you become pregnant while using fluticasone, call your doctor immediately. [7] X Trustworthy Source Mayo Clinic Educational website from one of the world’s leading hospitals Go to source

Do not use Flonase any more or less in either amount or frequency than your doctor has prescribed.

Also be careful not to get it in your eyes or mouth. Rinse thoroughly if you do.

Swelling of face, neck, feet, or ankles Difficulty breathing or swallowing Wheezing breaths Fatigue Hives Fever Unexpected bruising.

The very first time you use a new bottle, press down on the pump six times to let off pressure. To re-prime a bottle you’ve used before, press down and release the pump until you see a fine spray.

Do not blow your nose after using the spray. [16] X Trustworthy Source Mayo Clinic Educational website from one of the world’s leading hospitals Go to source