If you have a saved game previously, it will be replaced and can no longer be recovered. Select “Brutal Mode” for the level, then proceed to giving your plague a name.

You can refer to the guide below for your Genetic setup, but you can choose whatever you see is effective for this level. Under the DNA Genes, choose “Cytochrome Surge. ” This will give you more DNA points whenever you pop an orange DNA. For the Travel Gene, Teracyte is advisable since it increases the chance of your plague to spread by land. It can cross borders as long as there’s enough host. The Evolution Gene should be Sympto-Stasis; this will make the plague easier to cure but the symptoms in the later part of the game doesn’t increase it’s DNA points requirement. This is a very important part of the strategy. You don’t have to worry about the Cure percentage in this stage since we will be using the ‘undetected’ approach until we have spread the plague in every part of world. Choose Genetic Mimic for your Mutation Gene. This will make the Parasite harder to cure, a good choice to counterbalance the Sympto-Statsis’ drawback. Lastly, Extremophile is the best option for your Environment Gene. This will give minor bonus in all environments, giving your Parasite a faint boost to enter nations with different types of climate.

Alternatively you can choose Saudi Arabia as it tends to infect the somewhat problematic Madagascar easier, and will spread to India quickly. If you choose India, the very first country that will be infected is most likely China. From there, the plague will spread faster and effectively since there are already a good number of host from India. After choosing your starting country, pop red and yellow bubbles to gather DNA points. Don’t forget to speed up your game to fast forward. You can find the option at the upper right of the screen.

Continue popping bubbles until you have gathered enough DNA points. Don’t add any symptoms or transmissions yet until you have evolved Symbiosis to its last Level.

Cyst is a painful lump containing pockets of pathogen which has a slight chance of bursting which can spread the Parasite. To put it simple, this symptom help increase the infectivity of your plague. Anaemia is a decrease in red blood cells or hemoglobin in the blood which can lead to hypoxia in the organs. This, too, increases the infectivity. Generally, evolving Symptoms at the earliest part will make humans aware of the plague, causing them to do research for the cure before you could even infect the whole world, but with the Parasite’s ability, Symbiosis, level 1 and level 2 symptoms are less likely noticed.

To add infectivity, we need to evolve Air and Water. These Genes can be found under the “Transmissions” tab. Evolve Water to 1 while Air should be Level 2.

“Lethal” will alarm the researchers, causing them focus on creating the Cure to eradicate your plague so make sure to keep Lethal low.

To stop this, evolve your Drug Resistance to 1. It can be found under the “Abilities” tab. Your plague will dramatically spread to other nation in decent speed, especially in poor countries.

This will strengthen your Parasite and will be able to spread quickly in cold countries such as Canada, Greenland, etc. Don’t forget to devolve symptoms with Lethal. There’s no need to evolve the Hot Resistance since you have lay your plague in India; it is already immune to warm climates. Save your DNA points for the later part of the game.

After this, return to your game and pop more bubbles and wait until all the nations are infected, or until a message “There are no healthy people left in the world” appears on your screen.

Go to your “Symptoms” tab and then evolve the following: Paralysis, Total Organ Failure, and Coma. This will start killing people and cure will start to increase, as well.

This will reduce the cure amount which will increase your final score. Before the cure reaches 50%, humanity has been eradicated by your killer Parasite. Congratulations, you won the game!